| abstract |
An antibody that binds to the second extracellular loop of human C5aR, wherein the variable region of the heavy chain of said antibody comprises a sequence of CDR1, one of CDR2 and one of CDR3, wherein said CDR sequences comprise the sequences SEQ ID 9, 10 and 11, and wherein the variable region of the light chain of said antibody comprises a sequence of CDR1, one of CDR2 and one of CDR3, wherein said CDR sequences comprise sequences SEQ ID 13, 14 and 15, wherein the variable region of the heavy chain of said antibody comprises a sequence at least 90% identical to SEQ ID NO: 12, wherein the variable region of the light chain of said antibody comprises a sequence of at least 90% identical to SEQ ID NO: 16, and wherein the antibody has an Fc hinge region of IgG1 isotype. |