http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2693593-T3
Outgoing Links
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|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b4f16e71d2cc81c549e81470d725e224 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aca152ba4602da5909c80dcbdef46ef5 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1082 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2863 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-79 |
| filingDate | 2013-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7bbe49abcd706a203573a7d8f2abd6be http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5d4cc1c43152f07e7d8666ef85c30ac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74fa39136059352a6b4b80e07e0b7d40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6677d7f4dbab7bd38d35147192d0af2f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ffb9dccaef3e975a7b45b11c8e3707d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13f04b4dd17a8b57980e2f246feac83e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8f230db0434edf9bdb421d212ca2aaa |
| publicationDate | 2018-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2693593-T3 |
| titleOfInvention | Composition and method for the diversification of target sequences |
| abstract | A recombinant polynucleotide vector for integrating a target gene into a locus of the heavy chain of the chicken immunoglobulin gene, comprising: (a) a region of the nucleic acid sequence downstream of the chicken immunoglobulin VH gene that comprises a sequence homologous to the 5 'side of the start codon of endogenous genomic DNA encoding a chicken immunoglobulin VH gene; (b) a target gene comprising a rearranged chicken immunoglobulin VH-D-JH gene that has been isolated from a population of cells of the chicken bag of Fabrizio, wherein said VH-D-JH gene is rearranged accordingly so that the genes VH, D and JH are together; and (c) a region of the nucleic acid sequence downstream of the chicken immunoglobulin JH gene comprising a sequence homologous to the 3 'side of the splice site of endogenous genomic DNA encoding a JH immunoglobulin gene of chicken, in which the target gene, after being integrated into the chicken immunoglobulin heavy chain locus of a DT40 cell, is capable of undergoing either or both of (i) somatic hypermutation in a coding sequence of the VH region immunoglobulin, and (ii) gene conversion between a rearranged chicken immunoglobulin VH encoding nucleic acid sequence and a DT40 VH pseudogene nucleic acid sequence. |
| priorityDate | 2012-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 280.