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grantDate 2018-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2018-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2693374-T3
titleOfInvention Pharmaceutical formulations of opioid receptor modulator
abstract A solid pharmaceutical dosage formulation which is a deterrent abuse formulation comprising approximately 5-20% by weight of 5 - ({[2-amino-3- (4-carbamoyl-2,6-dimethyl-phenyl) - propionyl] - [1- (4- phenyl-1H-imidazol-2-yl) -ethyl] -amino} -methyl) -2-methoxy-benzoic acid, about 60-80% by weight of lost microcrystalline cellulose, of about 0.45-1.0% by weight of colloidal silica, about 2-8% by weight of crospovidone, about 1-20% by weight of mannitol, and about 0.45-1% by weight of stearate magnesium, wherein said formulation optionally further comprises i) a film coating, or / and ii) at least one inert pharmaceutical excipient selected from a pharmaceutically acceptable dissolution rate modifying agent, a pharmaceutically acceptable plasticizer, a pharmaceutically acceptable coloring agent , a pharmaceutically acceptable opacifier, a pharmaceutically antioxidant Acceptable tea, a pharmaceutically acceptable preservative, a flavoring agent, a neutralizing agent, a buffering agent and combinations thereof.
priorityDate 2013-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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