| abstract |
Oral pharmaceutical or dietetic form comprising sustained-release depot-type microparticles of at least one active principle (AP) and at least one agent D which is a pharmaceutically acceptable compound whose speed or capacity to hydrate or to solvate is greater than 5 in aqueous medium free of alcohol than in alcoholic solution, agent D being mixed with the deposit-type microparticles and representing from 2 to 30% in w / w of the total mass of the mixture said oral pharmaceutical form resisting the immediate discharge of the dose of PA in the presence of alcohol said oral pharmaceutical or dietary form being presented in the form of a capsule, said agent D being chosen from the group consisting of: - cross-linked carboxyalkyl celluloses: cross-linked carboxymethyl celluloses (for example, croscarmellose sodium), - (hydroxy ) (alkyl) celluloses (eg, hydroxypropylcellulose, hydroxypropylmethylcellulose), - carboxyalkylcelluloses (eg, carboxyme tilcellulose) and its salts, - polysaccharides, - proteins, - and their mixtures. |