abstract |
Process for preparing compounds of formula (III) ** Formula ** in which Ar represents the group ** Formula ** wherein R1, R2, R3, R4 and R5 are each the same or different and each independently represents hydrogen, amino, cyano, nitro, halogen, represent C1-C6 alkyl, C1-C6 thioalkyl, thiophenyl, C1-C6 alkoxy, C6-C10-aryl-oxyl, phenyl, -CO C6-C10 aryl, -CO-C1-C3 alkyl, -COO -C1-C6 alkyl or -COO-C6-C10 aryl, if necessary substituted by halogen, the radical Ar may also additionally represent a heteroaromatic radical or the radical Ar may also represent 1- or 2-naphthyl, and R6 and R7 represent each one independently C1-C8 alkyl, where appropriate substituted, phenyl, aryl or represents NR8R9, wherein R8 and R9 are each the same or different and each independently represent C1-C4 alkyl, or represent phenyl if substituted with C1-C3 alkyl, which may be the case substituted with fluorine or chlorine, with nitro, cyano or C1-C3-amino dialkyl, or together with the nitrogen atom to which they are attached represent a saturated or unsaturated, substituted or unsubstituted cycle, characterized in that the aryl or heteroaryl halides of formula (I) ** Formula ** in which Hal represents chlorine are reacted , bromine or iodine, and Ar has the meanings indicated above, with malonic esters of formula (II) ** Formula ** in which R6 and R7 each have the meanings indicated above, in the presence of a palladium catalyst, of a phosphine ligand and A) of an inorganic base and a phase transfer catalyst using an organic solvent if necessary. |