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filingDate 2008-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2018-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2018-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2690274-T3
titleOfInvention Biologically active immobilized entities, which have a high degree of biological activity
abstract A medical device comprising: a substrate material; a polymeric coating material attached to at least a portion of a surface of said substrate material, a plurality of biologically active entities having heparin cofactor II binding activity covalently attached to at least a portion of said polymeric coating material; and a biologically compatible composition covalently or non-covalently combined with biologically active entities and optionally covalently or non-covalently combined with the substrate material and / or said polymeric coating material; wherein said biologically active entities comprise dermatan disulfate and have a binding activity to heparin cofactor II of at least 5 picomoles of heparin cofactor II per square centimeter (pmol / cm2) and where the biologically compatible composition comprises a polysaccharide or it is polyethylene glycol.
priorityDate 2007-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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