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grantDate 2018-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2018-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2688882-T3
titleOfInvention Heat stable nanoparticle preparations and associated methods
abstract A method for stabilizing a nanoparticle preparation comprising the steps of: (a) purifying a composition to form a purified composition, wherein the purified composition comprises at least one nanoparticle disposed in a carrier fluid, the nanoparticle comprising a core and an attached shell to the core, the shell comprising a ligand species in which said ligand species comprises a phosphate, a phosphonate or a combination thereof and also comprises a functional group of poly (ethylene glycol) (PEG) and in which said purification removes the species ligand not bound to the nucleus; (b) adding an amount of the ligand species to the purified composition to form a preparation, wherein at least a portion of the added amount of the ligand species remains unbound to the core; and (c) sterilization of the preparation; wherein the coat ligand species and the ligand species added to the purified composition are structurally identical.
priorityDate 2012-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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