abstract |
A compound of the formula ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: each R / is independently selected from H and QR1; each Q is independently selected from a link, CO, CO2, NH, S, SO, SO2 or O; each R1 is independently selected from H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, heteroaryl, C1-C10 cycloalkyl, halogen, C1-C10 alkylaryl, C1-C10 alkyl-heteroaryl or C1-C10 heterocycloalkyl ; each L is independently selected from a 5-10 membered nitrogen-containing heteroaryl group; ** Formula ** W is the zinc -CONHOH binding group of structure: each R2 is independently hydrogen or C1 to C6 alkyl; and R3 is an aryl or heteroaryl; each aryl or heteroaryl may be substituted with up to three substituents selected from C1-C6 alkyl, hydroxy, C1-C3 hydroxyalkyl, C1-C3 alkoxy, C1-C3 haloalkoxy, amino, C1-C3 alkylamino, bis C1-C3 alkylamino, acylamino C1-C3, C1-C3 aminoalkyl, mono (C1-C3 alkyl) amino C1-C3 alkyl, bis (C1-C3 alkyl) amino C1-C3 alkyl, C1-C3 acylamino, C1-C3 alkyl sulfonylamino, halo, nitro, cyano, trifluoromethyl, carboxy, C1-C3 alkoxycarbonyl, aminocarbonyl, mono C1-C3 alkyl aminocarbonyl, bis C1-C3 alkylcarbonyl, -SO3H, C1-C3 alkylsulfonyl, aminosulfonyl, C1-C3 alkyl alkylsulfonyl and bis C1-C3 alkyl aminosulfon ; and each alkyl, alkenyl or alkynyl may be substituted with halogen, NH2, NO2 or hydroxyl. |