http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2687795-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eac2f8eff077c4682236f6b66083d39a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-605 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-605 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 |
| filingDate | 2012-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6016270f7769889b7bf38f8fd5b5da6f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60ad196fe206e251fa71b4dee5944f73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a889ff0bd4656dedfe159cb2f2019407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5828b8fc4c2862efc8c1d5c12a4871f |
| publicationDate | 2018-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2687795-T3 |
| titleOfInvention | Method for preparing exenatide |
| abstract | A method for the preparation of exenatide, characterized by comprising the following steps: Step 1: serine-resin is obtained by means of a first coupling between serine and the resin; Step 2: Peptide-resin of SEQ ID NO: 1 is obtained by a second coupling of said serinarin sequentially with amino acids; Step 3: Peptide-resin is obtained from SEQ ID NO. 2 by a third coupling between the histidine containing the protecting group or a salt thereof with said peptide-resin of SEQ ID NO. 1, and the exenatide is finally obtained after cutting and purification; wherein the protecting group-containing histidine or a salt thereof in step 3 has the structure as shown in formula IV: Boc-His (Boc) -OH.DCHA Formula IV, wherein step 3 comprises obtaining exenatide -resin in a solvent in the presence of a coupling agent and an organic base, where the coupling agent is HATU and HOAt. |
| priorityDate | 2012-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 224.