abstract |
A cosmetic method for improving wrinkles by inhibiting heparanase activity, which comprises the step of administering to a subject in need, one or more cyclic carboxamide derivative (s) selected from the group consisting of 2-imidazolidinone , 1- (2-hydroxyethyl) -2-imidazolidinone and 1- (2-hydroxyethyl) -2-pyrrolidone, or a salt thereof, as an active ingredient. |