| abstract |
Compound of formula (I), ** Formula ** or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, in which: R1 represents H; optionally substituted alkyl (wherein one or more substituents are included among the optional substituents, each of which is independently selected from C1-6 alkoxy, NH2, -NH-C1-3 alkyl and -N (C1-3 alkyl) 2); -C (O) O-alkyl; haloalkyl, haloalkoxy or -alkylaryl, each R2 independently represents H, optionally substituted alkyl (in which optional substituents include one or more substituents, each independently selected from C1-6 alkoxy, NH2, -NH-C1-3 alkyl and -N (C1-3 alkyl) 2); -alkylaryl; optionally substituted carbocyclyl (wherein one or more substituents are included among the optional substituents, each independently selected from C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy and halo); optionally substituted heterocyclyl (in which the optional substituents include one or more substituents each independently selected from C 1-6 alkyl, C 1-6 alkoxy, -C (O) O-C 1-6 alkyl, -C (O) - C1-6 alkyl and C (O) NH-C1-6 alkyl; -NH-alkyl; - N (alkyl) 2; amino, hydroxyl, alkoxy or halo, n represents 0, 1 or 2, R3 represents H or alkyl, R4 represents H or alkyl, R5 represents H or alkyl, W and X each independently represent C> = O, C> = S or CH2, Y represents 6-element monocyclic aryl or heteroaryl and Z represents aryl or heteroaryl. |