http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2683869-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_36f12690a646f4748ac2bdf53149359a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-317 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3515 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3521 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-319 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-712 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1135 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713 |
| filingDate | 2015-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b093c8920ca0000e896b83ba2eb39820 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8e9addc0be3a9731c8aa120c0cabc13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77823a3b468e9b77025c6dbcc923cd95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4223f0bf50f290ffc9427edb901d83d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45830134421d5fd67ed1d45314af34b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a6f8e7fc3b64bc6b67d3f076fcb287b |
| publicationDate | 2018-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2683869-T3 |
| titleOfInvention | Methods and compositions to prevent ischemia-reperfusion organ injury |
| abstract | A temporary inhibitor of a p53 gene for use in the prophylaxis of ischemic reperfusion injury (IRI) in a kidney at risk of IRI from a donor age 35 or older, where the inhibitor is to contact the kidney, where contacting the kidney with the temporary inhibitor comprises administering the temporary inhibitor to a subject to whom the kidney has been transplanted at risk of IRI, or contacting the kidney with the temporary inhibitor ex vivo before kidney transplantation to a recipient , wherein the inhibitor is a synthetic small interfering ribonucleic acid (siRNA) having the structure: 5 'UGAAGGGUGAAAUAUUCUC 3' (antisense chain) (SEQ ID NO: 37) 3 'ACUUCCCACUUUAUAAGAG 5' (chain in direction) (SEQ ID NO : 36) wherein each of A, C, U and G is a ribonucleotide and each consecutive ribonucleotide is attached to the next ribonucleotide by a covalent bond; and wherein the ribonucleotides alternated in both the antisense chain and the sense chain are ribonucleotides modified with 2'-O-methyl sugar and a ribonucleotide modified with 2'-O-methyl sugar is present both at the 5 'end and in the the 3 'end of the antisense chain and an unmodified ribonucleotide is present at both the 5' end and the 3 'end of the chain in the sense; or wherein the inhibitor is a double stranded ribonucleic acid (dsRNA) selected from ** Table ** where: A, U, G, C - designates an unmodified ribonucleotide; A, U, G, C - designates a ribonucleotide modified with 2'-O-methyl sugar; a, u, c, g - designates a nucleotide attached to an adjacent nucleotide (5 '> 3') by a 2'-5 'internucleotide phosphate bond; C3 - designates 1,3-propanediol, mono (dihydrogen phosphate) also identified as a 3-hydroxypropane-1-phosphate protecting moiety [CAS RN: 13507-42-1]; C3C3 - designates a protection residue consisting of two consecutive C3 molecules; dT - designates thymidine; dT $ - designates thymidine without terminal phosphate; pi - designates 3'-phosphate; 5'-phos - designates 5'-phosphate. |
| priorityDate | 2014-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 193.