| abstract |
A fusion protein comprising interleukin 4 and interleukin 10 for use in the prevention or treatment of osteoarthritis; chronic pain or a condition characterized by local or systemic inflammation, immune activation and / or lymphoproliferation selected from the group consisting of: sepsis, adult dyspnea syndrome, allo- and xenotransplantation, dermatitis, inflammatory bowel disease, sarcoidosis, allergies, psoriasis, ankylosing spondyloarthritis, autoimmune diseases, glomerulonephritis, immune complex-induced vasculitis and other forms of vasculitis, multiple sclerosis, Sjogren's disease, gout, lymphoproliferative diseases, non-Hodgkin lymphoma and chronic lymphocytic leukemia of B lymphocytes, burn injuries, multiple trauma, stroke, myocardial infarction, atherosclerosis, diabetes mellitus, extracorporeal dialysis and blood oxygenation, ischemia-reperfusion injury, toxicity induced by in vivo administration of cytokines or therapeutic monoclonal antibodies, chronic pain syndrome and neu pain clothing and / or inflammatory. |