| abstract |
Polymeric nanoparticle comprising the active ingredients finasteride and minoxidil, wherein said polymeric nanoparticle in the form of a nanocapsoid can be obtained by: (i) an organic phase comprising: (a) a hydrophobic polymer, which is a biodegradable polymer of the group of polyesters having a melting point of less than 120 ° C, which is a poly (ε-caprolactone), (b) a fixed oil, which is selected from medium chain triglycerides, (c) a low HLB lipophilic surfactant, which has a value in the range of 3 to 6, which is a sorbitan monostearate, (d) an organic solvent, which is acetone, (e) a cosolvent, which is ethanol, and (f) finasteride; and (ii) an aqueous phase comprising: (g) a hydrophilic surfactant, which is polysorbate 80, (h) minoxidil, and (i) water. |