| abstract |
A composition for use in the contribution of one or more heterologous compounds to a subject, the composition comprising a nanoparticle comprising one or more heterologous compounds and a modified human papillomavirus (HPV) L1 protein that has a reduced immunogenicity in relation to to wild HPV16, wherein the amino acid sequence of the modified HPV L1 protein corresponds to the amino acid sequence of SEQ ID NO: 1 comprising amino acid substitutions D273T, N285T and S288N. |