| abstract |
A compound of formula (I) ** Formula ** in which A is CH2, CH2CH2, CH2CO or is absent; R1 is tert-butyl, tert-butylamino, 2,2-dimethylpropyloxy or halogen; R2 and R3, together with the nitrogen atom to which they are attached, form pyrrolidinyl, substituted pyrrolidinyl, thiazolidinyl, alkylpiperazinyl, 2-oxa-7-azaspiro [3.4] octyl, 2-oxa-6-azaspiro [3.3] heptyl, azetidinyl , substituted azetidinyl, 2,2-dioxo-2λ6-thia-6-azaspiro [3.3] heptyl or halo-5-azaspiro [2.4] heptyl, wherein substituted pyrrolidinyl is substituted pyrrolidinyl with one to four independently selected halogen substituents , hydroxyl, alkyl, hydroxyalkyl, cyano, alkylcarbonylamino, alkylcarbonyloxy and haloalkyl and wherein substituted azetidinyl is azetidinyl substituted with one or two substituents selected from halogen, hydroxyl, alkyl and haloalkyl; and R4 is hydrogen, phenyl, halophenyl, alkylphenyl, haloalkylphenyl, pyridinyl, halopyridinyl, cycloalkyl, alkyl, alkyloxyadiazolyl, oxolanyl, alkyltetrazolyl, alkoxy, alkylsulfonylphenyl, haloalkyl, alkoxyphenyl, dioxothiethanyl, cycloalkyl-alkyl-alkyl-cycloalkyl-alkyl-alkylalkyl-cycloalkyl-alkyl-cycloalkyl-alkyl-cycloalkyl-alkyl-alkyl-cycloalkyl-alkyl-cycloalkyl-alkyl-cycloalkyl-alkyl-cycloalkyl-alkyl-cycloalkyl-alkyl-cycloalkyl-alkyl-cycloalkyl-alkyl-cycloalkyl-alkyl-cycloalkyl-alkyl-cycloalkyl-alkyl-cycloalkyl-alkyl-cycloalkyl-alkyl-cycloalkyl-alkyl-cycloalkyl-1-alkyl group or to a pharmaceutically acceptable salt or ester thereof; provided that 2-chloro-6- (1-pyrrolidinyl) -9H-purine; 2-Chloro-9- (phenylmethyl) -6- (1-pyrrolidinyl) -9H-purine; and 1- [2-Chloro-9- (1-methylethyl) -9H-purin-6-yl] -3-pyrrolidinol; be excluded. |