abstract |
A process for preparing tert-butyl (((3aR, 4R, 6aR) -5-fluoro-2,2-dimethyl-6 - ((trityloxy) methyl) -4,6a-dihydro-3aHcyclopenta [d] [1,3 ] dioxol-4-yl) oxy) diphenylsilane (9) comprising: hydrolyzing a tert-butyl boronic acid intermediate (((3aR, 4R, 6aR) -5-iodo-2,2-dimethyl-6- ( (trityloxy) methyl) -4,6a-dihydro-3aH-cyclopenta [d] [1,3] dioxol-4-yl) oxy) diphenylsilane (8), and react the hydrolyzate with 1-chloromethyl bis (tetrafluoroborate) -4-fluoro-1,4-diazoniabicyclo [2.2.2] octane to obtain tert-butyl (((3aR, 4R, 6aR) -5-fluoro-2,2-dimethyl-6 - ((trityloxy) methyl) - 4,6adihydro-3aH-cyclopenta [d] [1,3] dioxol-4-yl) oxy) diphenylsilane (9). |