| abstract |
Nanoconjugates formed by dendritic molecules and peptides as antitumor agents against cancer # The present invention relates to the formation of nanoconjugates that exhibit antitumor activity, mainly against advanced prostate cancer, but without ruling out others. The nanoconjugates are formed by dendritic systems (dendrimers or dendrons) and neuropeptides. Dendritic molecules are mainly of carbosilane structure with ammonium functions in the periphery. The peptides are preferably from the glucagon / secretin family (eg, VIP, GHRH, PACAP). The combination of these two systems results in a nanoconjugate with anticancer properties, different from those of their precursors separately. The antitumor activity is reflected in the inhibition of growth and death of tumor cells of advanced prostate cancer (PC3) and in addition these nanoconjugates favor cell adhesion and prevent processes of migration of tumor cells, that is, processes of metastasis. |