http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2674531-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427 |
| filingDate | 2015-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a49181ec94b4f801312da944a8971242 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8964860b391fcd3824c6d0bfaffea7ef |
| publicationDate | 2018-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2674531-T3 |
| titleOfInvention | Modulators of the receptor coupled to the protein g 40 (gpr40) of pyrrolidine for the treatment of diseases such as diabetes |
| abstract | A compound of Formula (I): ** Formula ** or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph or a solvate thereof, wherein: X is independently selected from: a bond , O, S, NH, N (C1-4 alkyl), CH2, CH2CH2, CH (C1-4 alkyl), OCH2, CH2O, OCH2CH2 and CH2CH2O; Ring A is independently ** Formula ** Ring B is independently a 4- to 7-membered saturated heterocycle containing carbon atoms, the nitrogen atom shown in Ring B and an additional 0-1 heteroatom selected from N, O and S; and ring B is substituted with 0-4 R2; R1 is independently ** Formula ** phenyl, benzyl, naphthyl or a 5-10 membered heteroaryl containing carbon atoms and 1-4 heteroatoms selected from N, NR11, O and S; wherein said phenyl, benzyl, naphthyl and heteroaryl are each substituted with 0-3 R6; R2, in each case, is independently selected from:> = O, OH, halogen, C1-6 alkyl substituted with 0-1 R12, C1-6 alkoxy substituted with 0-1 R12, C1-4 haloalkyl substituted with 0-1 R12, C1-4 haloalkoxy substituted with 0-1 R12, - (CH2) m-C3-6 carbocycle substituted with 0-1 R12 and - (CH2) m- (5 to 10 membered heteroaryl containing carbon atoms and 1 -4 heteroatoms selected from N, NR11, O and S); wherein said heteroaryl is substituted with 0-1 R12; when two R2 groups are attached to two different carbon atoms, they can be combined to form a bridge of 1 to 3 member carbon atoms over the B ring; when two R2 groups are attached to the same carbon, they can be combined, together with the carbon atom to which they are attached, to form a 3 to 6 member carbon atom containing a spiro ring; R3 is independently selected from: C1-6 alkyl substituted with R10, C2-6 alkenyl substituted with R10, C2-6 alkynyl substituted with R10, C1-4 haloalkyl substituted with R10, -O (CH2) 1-2O (CH2) 1 -4R10, OR9, SR9, C (O) OR9, CO2R9, S (O) R9, SO2R9 and CONHR9; R4 and R4a are independently selected from: H, halogen, C1-6 alkyl, C1-6 alkoxy and - (CH2) m-C3-6 carbocycle; R5, in each case, is independently selected from: halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl and C1-6 haloalkoxy; R6, in each case, is independently selected from: halogen, OH, C1-4 alkylthio, CN, SO2 (C1-2 alkyl), N (C1-4 alkyl) 2, C1-4 haloalkyl, C1-4 haloalkoxy, C1 -8 alkyl substituted with 0-1 R7, C1-6 alkoxy substituted with 0-1 R7, - (O) n- (CH2) m- (C3-10 carbocycle substituted with 0-2 R7) and - (CH2) m - (5-10 membered heteroaryl containing carbon atoms and 1-4 heteroatoms selected from N, NR11, O and S); wherein the heteroaryl is substituted with 0-2 R7; R7, in each case, is independently selected from: halogen, OH, C1-4 alkyl, C2-4 alkenyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 haloalkyl, C1-4 haloalkoxy, SCF3, CN, NO2 , NH2, NH (C1-4 alkyl), N (C1-4 alkyl) 2, SO2 (C1-2 alkyl) and phenyl; R8 is independently selected from: H and C1-4 alkyl; R9, in each case, is independently selected from: C1-6 alkyl substituted with R10 and C1-4 haloalkyl substituted with R10; R10, in each case, is independently selected from: CN, C1-4 alkoxy, C1-4 haloalkoxy, CO2 (C1-4 alkyl), SO2 (C1-4 alkyl) and tetrazolyl; R11, in each case, is independently selected from: H, C1-4 alkyl and benzyl; R12, in each case, is independently selected from: OH, halogen, CN, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, CO2 (C1-4 alkyl) and tetrazolyl; m, in each case, is independently 0, 1 or 2; and n, in each case, is independently 0 or 1. |
| priorityDate | 2014-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 399.