| abstract |
A compound of Formula (I) ** Formula ** in which D is N, CH, or C-F; R1 is (C1-C4) alkyl optionally substituted with one, two or three substituents each independently selected from fluoro and cycloalkyl (C3-C6); R2 is fluoro or (C1-C4) alkyl; R3 is H, (C1-C4) alkyl, or (C3-C6) cycloalkyl; R4 is H, -C1-C4 alkyl, - (C1-C4 alkyl) p-C3-C6 cycloalkyl, - (C1-C4 alkyl) p-heterocyclyl (C3-C6), - ( ((C1-C4) alkyl) p-aryl, or - (((C1-C4) alkyl) p-heteroaryl in which R4 is optionally substituted with one, two, three, or four substituents selected from halo, cyano, oxo , aminyl, iminyl, -OH, -C1-C4 alkyl, -fluoroalkyl (C1-C4), -alkoxy (C1-C4), -cycloalkoxy (C3-C6), -fluoroalkoxy (C1-C4), - ( (C1-C4) alkyl) q-COOH, - ((C1-C4) alkyl) q-cycloalkyl- (C3-C6) - COOH, - ((C1-C4) alkyl) q-heterocyclyl (C3-C6) - COOH, - (C1-C4 alkyl) q-aryl-COOH, - ((C1-C4) alkyl) q-heteroaryl-COOH, - O - (((C1-C4 alkyl)) q-COOH, -O - (((C1-C4) alkyl) q-aryl-COOH, -O - (((C1-C4) alkyl) q-heteroaryl-COOH, - ((C1-C4) alkyl) (C3-C6) cycloalkyl, - ((C1-C4) alkyl) q-heterocyclyl (C3-C6), - ((C1-C4) alkyl) q-aryl, - ((C1-C4) alkyl) q-heteroaryl, - C (O) - (C1-C4) alkyl, -C (O) -alkoxy (C1-C4), -C (O) -cycloalkyl (C3-C6), -C (O) -heterocyclyl (C3-C6), -C (O ) - NR6R7, -C (O) - ((C1-C4) alkyl) q-aryl, -C (O) - (a (C1-C4) alkyl) q-heteroaryl, -NR6R7, -NR6-C (O) -R7, - ((C1-C4) alkyl) q-O20 aryl, - ((C1-C4) alkyl) qO-heteroaryl , -S (O) 2-R7, and -S (O) 2-NR6R7; or R3 and R4 can be joined to form a fully saturated or partially saturated 4 to 10 membered ring system optionally substituted with one, two, three, or four substituents selected from halo, cyano, -OH, - (C1-C4) alkyl , -fluoroalkyl (C1-C4), -alkoxy (C1-C4), -cycloalkoxy (C3-C6), -fluoroalkoxy (C1-C4), - (alkyl (C1-C4)) q- COOH, - (alkyl ( C1-C4)) q-cycloalkyl (C3-C6) -COOH, - ((C1-C4) alkyl) q-heterocyclyl (C3-C6) -COOH, - ((C1-C4) alkyl) q-aryl- COOH , - ((C1-C4) alkyl) q-heteroaryl-COOH, -O - (((C1-C4) alkyl) q-COOH, -O - (((C1-C4) alkyl) q-aryl-COOH, -O - (((C1-C4) alkyl) q-heteroaryl-COOH, -C1-C4 alkyl) q-C3-C6 cycloalkyl, - (((C1-C4) alkyl) q-heteroaryl, - C (O) - (C1-C4) alkyl, -C (O) -C3-C6 cycloalkyl, -C (O) -heterocyclyl (C3-C6), -C (O) -aryl, -C (O ) -heteroaryl, -C (O) -NR6R7, - C (O) alkyl- (C1-C4) -aryl, -C (O) alkyl- (C1-C4) -heteroaryl, -NR6R7, -NR6-C ( O) -R7, -O-aryl, -O-heteroaryl, - (C1-C4) alkyl -O-aryl, -C1-C4 alkyl -O-heteroaryl, -O-(C1-C4) alkyl -aryl , and -O-(C1-C4) alkyl-heteroaryl; R5 is H, F, or cyano; R6 is H, (C1-C4) alkyl, or -S (O) 2-R7; R7 is H, (C1-C4) alkyl, (C3-C6) cycloalkyl, (C3-C6) heterocyclyl, aryl, or heteroaryl; n is 0, 1, 2 or 3; p is 0 or 1; and q is 0 or 1; or a pharmaceutically acceptable salt thereof. |