| abstract |
A method of purifying inter-alpha inhibitory proteins (IαIp proteins), a method comprising: binding, in a chromatography step or a solid phase extraction step, blood-derived IαIp proteins, a fraction of blood plasma, or a fraction plasma intermediate to a monolithic or particle-based support comprising an immobilized anion exchange ligand; and washing, in a washing step, the IαIp proteins bound to the support by exposure to a washing buffer having a pH of 3.6 or less. |