http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2672581-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_981a37900e6991fb373304ed2ba5a703 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N43-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-12 |
| filingDate | 2015-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a5f545837ab911f3eb6dab35e57ce1e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02dd0df4be77ba478bf148d1d3c8e9bf |
| publicationDate | 2018-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2672581-T3 |
| titleOfInvention | Process for the preparation of 3,5-bis (haloalkyl) pyrazoles by means of the acylation of ketimines |
| abstract | A process for the preparation of 3,5-bis (haloalkyl) pyrazoles of the formula (Ia) and (Ib), ** Formula ** in which R1 and R3 are each independently selected from C1-C6 haloalkyl; R2 is selected from H, halogen, COOH, (C> = O) OR5, CN and (C> = O) NR6R7; R4 is selected from H, C1-C8 alkyl, aryl and pyridyl; R5 is selected from C1-12 alkyl, C3-8 cycloalkyl, C6-18 aryl, C7-19 arylalkyl and C7-19 alkylaryl; R6 and R7 are each independently selected from C1-12 alkyl, C3-8 cycloalkyl, C6-18 aryl, C7-19 arylalkyl and C7-19 alkylaryl, or where R6 and R7 together with the nitrogen atom to which they are together they can form a ring of four, five or six members characterized in that in step (A), the acid derivatives of the formula (II), ** Formula ** in which R1 is as defined above; X is F, Cl, Br or -OC (O) R1 are reacted, in the presence of a base, with the compounds of the formula (III), ** Formula ** in which R8 is selected from C1-12 alkyl , C3-8 cycloalkyl, C6-18 aryl, C7-19 arylalkyl, C7-19 alkylaryl and OR9; R9 is selected from C1-12 alkyl, C3-8 cycloalkyl, C6-18 aryl, C7-19 arylalkyl and C7-19 alkylaryl; R2 and R3 are as defined above; to form the compounds of the formula (IV) ** Formula ** in which R1, R2, R3, R5, R6, R7, R8, R9 are as defined above and that in step (B) the cyclization of (IV) in the presence of (V) NH2NHR4, in which R4 is as defined above, takes place under acidic conditions to form (Ia) and (Ib). |
| priorityDate | 2014-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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