| abstract |
An antibody or antigen-binding fragment thereof capable of binding prolactin receptor (PRLR), which comprises an antigen-binding domain with at least two sets of variable domain CDRs selected from a group consisting of: (1) any of the CDR sets of the heavy chain variable domain SEQ ID NO: 40, 41 and 42 or SEQ ID NO: 46, 47 and 42, and the CDR set of the light chain variable domain SEQ ID NO: 49 , 50 and 51; (2) any of the CDR sets of the heavy chain variable domain SEQ ID NO: 56, 57 and 58 or SEQ ID NO: 62, 63 and 58, and the CDR set of the light chain variable domain SEQ ID NO 65, 66 and 67; (3) any of the CDR sets of the heavy chain variable domain SEQ ID NO: 71, 72 and 73 or SEQ ID NO: 71, 77 and 73, and the CDR set of the light chain variable domain SEQ ID NO: 79, 80 and 81; and (4) any of the CDR sets of the heavy chain variable domain SEQ ID NO: 85, 86 and 87 or SEQ ID NO: 149, 150 and 87, and the CDR set of the light chain variable domain SEQ ID NO: 92, 93 and 94. |