http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2670769-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_40765ca9a78b54a8a76f781d159ad145 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 |
| filingDate | 2014-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71eb061332be17585ea718edb18d2bda http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73b79fbba892f0e75c1e70a81a31093d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_952982885aec286344cef45bcea29a7d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab63773787e0f55519bdbaeb1898a9e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cdb1d6cc71a7f1ef4088fa94b7fd497c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b43176d9b3cf77faeba7d6c33d56ae9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edfdecc2ce0b86d283118840abf71b6f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3511a3ad994356da7e65e7c2f31af2c8 |
| publicationDate | 2018-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2670769-T3 |
| titleOfInvention | Derivatives of (hetero) arylacetamide as antiretroviral agents |
| abstract | A compound of formula I: ** Formula ** wherein: A is ** Formula ** where each Z3a is independently selected from H and Z3; R1 is bicyclic heteroaryl or tricyclic heteroaryl, wherein the bicyclic heteroaryl or tricyclic heteroaryl has 4-9 carbon atoms and 1-5 heteroatoms in the ring system, and in which any bicyclic heteroaryl or tricyclic heteroaryl of R1 is optionally substituted with one or more Z4 groups; R2 is phenyl optionally substituted with one or more Z5 groups; each R3a and R3b is independently selected from H, halogen, (C1-C3) alkyl and haloalkyl (C1-C3), or R3a is selected from H, alkyl (C1-C3) and haloalkyl (C1-C3) and R3b is selected of -OH and -CN; Z1 is selected from phenyl, monocyclic heteroaryl and bicyclic heterocycle, in which the monocyclic heterocycle and the bicyclic heterocycle have 4-8 carbon atoms and 1-3 heteroatoms in the ring system, and in which any phenyl, monocyclic heteroaryl and bicyclic heterocycle of Z1 is optionally substituted with one or more groups Z1a or Z1b; each Z1a is independently selected from (C3-C7) carbocycle, aryl, heteroaryl, heterocycle, halogen, -CN, - ORn1, -OC (O) Rp1, -OC (O) NRq1Rr1, -SRn1, -S (O) Rp1 , -S (O) 2OH, -S (O) 2Rp1, -S (O) 2NRq1Rr1, -NRq1Rr1, -NRn1CORp1, - NRn1CO2Rp1, -NRn1CON Rq1Rr1, -NRn1S (O) 2Rp1, -NRn1S (-) NRn1S (O) 2NRq1Rr1, NO2, -C (O) Rn1, - C (O) ORn1, -C (O) NRq1Rr1 and -S (O) 2NRn1CORp1, where any carbocycle (C3-C7), aryl, heteroaryl and Z1a heterocycle is optionally substituted with one or more Z1c or Z1d groups; each Z1b is independently selected from (C1-C8) alkyl, (C2-C8) alkenyl and (C2-C8) alkynyl, wherein any (C1-C8) alkyl, (C2-C8) alkenyl and (C2-C8 alkynyl) ) of Z1b is optionally substituted with one or more Z1c groups; each Z1c is independently selected from (C3-C7) carbocycle, aryl, heteroaryl, heterocycle, halogen, -CN, -ORn2, -OC (O) Rp2, -OC (O) NRq2RR2, -SRn2, -S (O) Rp2 , -S (O) 2OH, -S (O) 2Rp2, -S (O) 2NRq2RR2, - NRq2RR2, -NRn2CORp2, -NRn2CO2Rp2, -NRn2CON Rq2RR2, -NRn2S (O) 2Rp2, -NRn2S (-) NRn2S (O2NRq2RR2, NO2, -C (O) Rn2, -C (O) ORn2, -C (O) NRq2RR2 and (C1-C8) heteroalkyl; each Z1d is independently selected from alkyl (C1-C8), alkenyl (C2 -C8), (C2-C8) alkynyl and halo (C1-C8) alkyl; each Rn1 is independently selected from H, (C1-C8) alkyl, alkenyl (C2-C8), alkynyl (C2-C8), carbocycle (C3 -C7), heterocycle, heteroaryl and aryl, wherein any carbocycle (C3-C7), aryl, heteroaryl and heterocycle of Rn1 is optionally substituted with one or more groups Z1c or Z1d, and in which any alkyl (C1-C8) , (C2-C8) alkenyl and (C2-C8) alkynyl of Rn1 is optionally substituted with one or more Z1c groups; each Rp1 is independently selected from (C1-C8) alkyl, alken ilo (C2-C8), alkynyl (C2-C8), carbocycle (C3-C7), heterocycle, heteroaryl and aryl, wherein any carbocycle (C3-C7) aryl, heteroaryl and heterocycle of Rp1 is optionally substituted with one or more Z1c or Z1d groups, and in which any (C1-C8) alkyl, (C2-C8) alkenyl and (C2-C8) alkynyl of Rp1 is optionally substituted with one or more Z1c groups; Rq1 and Rr1 are each independently selected from H, (C1-C8) alkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, carbocycle (C3-C7), heterocycle, heteroaryl and aryl, wherein any (C3 -C7) carbocycle, aryl, heteroaryl and heterocycle of Rq1 or Rr1 is optionally substituted with one or more Z1c or Z1d groups, and in which any (C1-C8) alkyl, (C2-C8) alkenyl and (C2-C8) groups alkynyl of Rq1 or Rr1 is optionally substituted with one or more Z1c groups; each Rn2 is independently selected from H, (C1-C8) alkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, (C3-C7) carbocycle, heterocycle, heteroaryl, aryl, (C1-C8) haloalkyl and ( C1-C8 heteroalkyl); each Rp2 is independently selected from (C1-C8) alkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, (C3-C7) carbocycle, heterocycle, heteroaryl, aryl, halo (C1-C8) alkyl and (C1-C8 heteroalkyl) -C8); Rq2 and Rr2 are each independently selected from H, (C1-C8) alkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, carbocycle (C3-C7), heterocycle, heteroaryl, aryl, (C1-C8) ) haloalkyl and (C1-C8) heteroalkyl; Z2 is selected from -ORs3-OC (O) Rp3, -OC (O) NRq3Rr3, -SRn3, -S (O) Rp3, -S (O) 2Rp3, -S (O) 2NRq3Rr3, -NRq3Rr3, - NRn3CORp3, -NRn3CO2Rp3, -NRn3S (O) 2Rp3, -NRn3S (O) 2ORp3 and -NRn3S (O) 2NRq3Rr3; each Z2a is independently selected from carbocycle (C3-C7), aryl, heteroaryl, heterocycle, halogen, -CN, - ORn4, -OC (O) Rp4, -OC (O) NRq4Rr4, -SRn4, -S (O) Rp4 , -S (O) 2OH, -S (O) 2Rp4, -S (O) 2NRq4Rr4, -NRq4Rr4, -NRn4CORp4, - NRn4CO2Rp4, -NRn4CON Rq4Rr4, -NRn4S (O) 2Rp4, -NRnpS (0) NRn4S (O) 2NRq4Rr4, NO2, -C (O) Rn4, - C (O) ORn4, -C (O) NRq4Rr4, in which any carbocycle (C3-C7), aryl, heteroaryl and heterocycle of Z2a is optionally substituted with one or more groups Z2b or Z2c; each Z2b is independently selected from (C1-C4) alkyl, (C1-C4) heteroalkyl and (C1-C4) haloalkyl; Each Z2c is independently selected from halogen, -CN, -ORn4, -OC (O) Rp4, -OC (O) NRq4Rr4, -SRn4, - S (O) Rp4, -S (O) 2OH, -S (O) 2Rp4, -S (O) 2NRq4Rr4, -NRq4Rr4, -NRn4 CORp4, -NRn4CO2Rp4, -NRn4CONRq4Rr4, - NRn4S (O) 2Rp4, -NRn4S (O) 2ORp4, -NRn4q (O) NR4Q4 (O) ) Rn4, -C (O) ORn4, -C (O) NRq4Rr4; each Rn3 is independently selected from H, (C1-C4) alkyl, (C2-C4) alkenyl, (C2-C4) alkynyl, carbocycle (C3-C7), heterocycle, heteroaryl and aryl, wherein any carbocycle (C3-C7) ), aryl, heteroaryl and heterocycle of Rn3 is optionally substituted with one or more Z2b or Z2c groups, and in which any (C1-C4) alkyl, (C2-C4) alkenyl or (C2-C4) alkynyl of R3 is optionally substituted with one or more Z2a groups; each Rp3 is independently selected from alkyl (C1-C4), haloalkyl (C1-C4), alkenyl (C2-C4), alkynyl (C2-C4), carbocycle (C3-C7), heterocycle, heteroaryl and aryl, where any carbocycle (C3-C7), aryl, heteroaryl and heterocycle of Rp3 is optionally substituted with one or more groups Z2b or Z2c, and in which any alkyl (C1-C4), alkenyl (C2-C4) and alkynyl (C2-C4) of Rp3 is optionally substituted with one or more Z2a groups; Rq3 and Rr3 are each independently selected from H, (C1-C4) alkyl, alkenyl (C2-C4), carbocycle (C3-C7), heterocycle, heteroaryl and aryl, wherein any carbocycle (C3-C7), aryl, heteroaryl and heterocycle of Rq3 or Rr3 is optionally substituted with one or more Z2b or Z2c groups, and in which any (C1-C4) alkyl and (C2-C4) alkenyl of Rq3 or Rr3 is optionally substituted with one or more Z2a groups , or Rq3 and Rr3 together with the nitrogen to which they are attached form a monocyclic heterocycle, bicyclic heterocycle or monocyclic heteroaryl, in which the monocyclic heteroaryl, bicyclic heteroaryl and bicyclic heterocycle have 1-8 carbon atoms and 1-4 heteroatoms in the ring system and wherein the monocyclic heterocycle, bicyclic heterocycle or monocyclic heteroaryl is optionally substituted with one or more Z2b or Z2c groups; each Rs3 is independently selected from alkenyl (C2-C4), alkynyl (C2-C4), carbocycle (C3-C7), heterocycle, heteroaryl and aryl, wherein any carbocycle (C3-C7), aryl, heteroaryl and heterocycle of Rs3 is optionally substituted with one or more Z2b or Z2c groups, and in which any (C2-C4) alkenyl or (C2-C4) alkynyl of Rs3 is optionally substituted with one or more Z2a groups, or Rs3 is (C1-C4) alkyl ) substituted with one or more Z2a groups; |
| priorityDate | 2013-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 164.