| abstract |
An oligopeptide compound comprising an interaction motif with PCNA, or a nucleic acid molecule comprising a sequence encoding said oligopeptide compound, preferably in which the nucleic acid molecule is comprised in a vector, for use in therapy, wherein the PCNA interaction motif is RWLVK (SEQ ID NO: 18), the oligopeptide compound is less than 70 amino acids and comprises a nuclear localized signaling sequence, KKKRK (SEQ ID NO: 125), and a sequence signaling signaling cell, RRRRRRRRRRR (SEQ ID NO: 73), and in which the order of the components is the reason for interaction with the PCNA-nuclear localization signaling sequence-cell penetration signaling sequence. |