http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-266986-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-72 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-72 |
| filingDate | 1961-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1961-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-266986-A1 |
| titleOfInvention | AN IMPROVED PROCEDURE FOR THE PREPARATION OF DELTA-TOCOPHEROL |
| abstract | Delta tocopherol is made by diazotizing 4-hydroxy-3-methyl-aniline in an acidic medium, converting the resulting diazonium salt into the corresponding monoacyl derivative by reaction with an alkanoic acid containing up to six carbon atoms, condensing the monoacyl derivative in the presence of an acid condensing agent with iso-phytol or phytol and hydrolysing the condensation product. Diazotization may be effected at 0-5 DEG C. in the presence of an alcohol or glacial acetic acid and hydrochloric or sulphuric acid using isoamyl nitrite or sodium nitrite. The diazonium salt is then heated to 50-80 DEG C. in the presence of acetic or propionic acid and then condensation is effected with isophytol or phytol in the presence of zinc chloride or boron trifluoride diethyl etherate at a temperature below 40 DEG C. The hydrolysis step may be effected by means of sulphuric acid in the presence of dioxene, or by reaction with lithium aluminium hydride or a Grignard reagent. |
| priorityDate | 1960-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.