http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2669750-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5fece74aa8c0cb73d997c194165159cc |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-52 |
| filingDate | 2015-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_591378bee978f0bb787ea96e97641718 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0d2a9a5af53ed5661f06f523c200cdb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ba7317d9395f8f71ac987873462e20b |
| publicationDate | 2018-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2669750-T3 |
| titleOfInvention | A process to produce saxagliptin |
| abstract | A process for producing saxagliptin of formula I ** Formula ** comprising a reaction of the intermediate compound of formula II, ** Formula ** in which Boc is tert-butyloxycarbonyl, with a silylating agent in the presence of a base, dehydration in addition to the resulting intermediate compound with the use of phosphorus oxychloride in the presence of imidazole and a base, producing Boc-saxagliptin of formula IV, ** Formula ** which is converted into saxagliptin of formula I by deprotection in an acidic environment, characterized by that a silylating agent selected from the group comprising bis (trimethylsilyl) acetamide, trimethylsilyl chloride, trimethylsilyl triflate and bis (trimethylsilyl) trifluoroacetamide is used. |
| priorityDate | 2014-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.