http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2669574-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b09f893b262cefd50c5e76c4b85d1c0a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-716 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D319-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-297 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-716 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-32 |
| filingDate | 2012-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f05a53b11dbb9f5bff7ba748967330d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b588bfee00b7e81d4817a61898e1d53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64f222aa91a5319ba306da95614c2ee8 |
| publicationDate | 2018-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2669574-T3 |
| titleOfInvention | Preparation of 3,5-dioxohexanoate ester in two stages |
| abstract | A method (B) for preparing a compound of formula (II); ** Formula ** R1 is Cl, Br and CN; method (B) comprises a step (C) and a step (B); step (B) is carried out after step (C); step (C) comprises a reaction (C) of a compound of formula (VI) with a compound (C) to provide a compound of formula (IV); ** Formula ** the compound (C) is selected from the group consisting in Cl2, Br2 and ClBr; step (B) comprises a reaction (B) of the compound of formula (IV), which has been prepared in step (C), with a compound of formula (V) in the presence of a base (B); ** Formula ** R1-IV and R3 are identical or different and, independently of each other, Cl or Br; the base (B) is selected from the group consisting of N (R4) (R5) R6, 1,4-diazabicyclo [2.2.2] octane, a hexamethyldisilazide, a C1-4 alkoxide salt of, a C1- carboxylate salt 10 of, a carbonate salt of, a hydrogen carbonate salt of, a phosphate salt of, a monohydrogen phosphate salt of or a dihydrogen phosphate salt of Na, K or Li, 1,8-diazabicyclo [5.4.0] undec-7-eno, NaNH2, KNH2, NaH, KH, CaH2, pyridine, pyridine substituted with 1 or 2 substituents, identical or different, selected, independently from each other, from the group consisting of methyl, ethyl and N (R14) R15; Morpholine, methylmorpholine, methylpiperidine, imidazole, benzimidazole, 2-methylimidazole, 4-methylimidazole, 2-ethylimidazole, 2-ethyl-4-methylimidazole, 2-isopropylimidazole, 2-phenylimidazole, 4-phenylimidazole, picoline, CsCO3, Na Ca (OH) 2, n-butyllithium (BuLi), sec.-butyllithium, tert-butyllithium, hexyl lithium, methyl lithium and mixtures thereof; R4, R5, R6 are identical or different and, independently of each other, are selected from the group consisting of H, C1-15 alkyl, C5-6 cycloalkyl, (C (R16) R17) mN (R12) R13 and phenyl, with the proviso that at least one of the remains R4, R5 or R6 is not H; R12 and R13 are identical or different and, independently of each other, H or C1-15 alkyl; m is 2, 3, 4, 5 or 6; R14 and R15 are identical or different and, independently of each other, methyl or ethyl; R16 and R17 are identical or different and, independently of each other, are selected from the group consisting of H, methyl and ethyl; with the proviso that, if R1 in formula (II) is CN, then step (B) further comprises a reaction (B-add), the reaction (B-add) is carried out after the reaction (B ), of the reaction product of the reaction (B) with a compound (B); compound (B) is selected from the group consisting of NaCN, KCN, Si (R9) (R10) (R11) CN, HCN, tetrabutylammonium cyanide, 1-cyanobenzotriazole and triselenium dicyanide and mixtures thereof; R9, R10 and R11 are identical or different and, independently of each other, are selected from the group consisting of C1-4 alkyl and phenyl. |
| priorityDate | 2011-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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