http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2669425-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2aa388e460f6cf478bd46c925c6ab10e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 |
| filingDate | 2013-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff55126bb1911a82ba1a498dbc9fc1c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_646ccea422ef5112d564fc9caf73b699 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24d6238da20d547e4d8a8e4178099c09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39f5553187265ffa4e3bb5a569fc250f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9d45dff84b5195d052bb1305c4bd5dc |
| publicationDate | 2018-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2669425-T3 |
| titleOfInvention | Procedure for the preparation of pazopanib or salts thereof |
| abstract | Process for the preparation of pazopanib of formula Ia or salts thereof ** (See formula) ** comprising: i) treating 2,3-dimethyl-6-nitro-2H-indazole with Raney nickel in the presence of gaseous hydrogen to obtain a compound of formula II; ** (See formula) ** ii) treat the compound of formula II at a temperature of 25 ° C to 30 ° C with 2,4-dichloropyrimidine in the presence of a base to obtain a compound of formula III; ** (See formula) ** iii) convert the compound of formula III into pazopanib of formula Ia or salts thereof; and iv) isolate the pazopanib of formula Ia or salts thereof in which stages i) and ii) are carried out in methanol as the sole solvent, avoiding heating and cooling procedures during stages i) and ii), and without isolating the compound of formula II from the reaction mixture. |
| priorityDate | 2012-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.