http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2669269-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dbaced0995cda76fea038c684318a8fe |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-9121 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-7028 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-485 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6842 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48 |
| filingDate | 2013-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6106a2d779dcea60f0d87841820811ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6efb81a92d89531f5ac561b6a8f7efab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e2c288e394a0933ee256afcd3afd4b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48bcf1c48743654218272166a908aed7 |
| publicationDate | 2018-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2669269-T3 |
| titleOfInvention | Phosphorylation inhibition of PRAS40, GSK3-beta or p70S6K1 as a marker for TOR kinase inhibitory activity |
| abstract | A method for detecting or measuring the inhibition of TOR kinase activity in a patient, comprising measuring the amount of PRAS40, GSK3β or phosphorylated p70S6K1 in blood, skin, tumor and / or circulating tumor cells in a biological sample of said patient, before and after administration of 7- (6- (2-hydroxypropan-2-yl) pyridin-3-yl) -1- (trans-4-methoxycyclohexyl) -3,4-dihydropyrazine [2,3 -b] pyrazin-2 (1H) -one, or a pharmaceutically acceptable salt, clathrate or solvate of said patient, in which PRAS40, GSK3β or p70S6K1 less phosphorylated in said biological sample obtained after administration of 7- (6- (2-Hydroxypropan-2-yl) pyridin-3-yl) -1- (trans-4- methoxycyclohexyl) -3,4-dihydropyrazino [2,3-b] pyrazin-2 (1H) -one, or a pharmaceutically acceptable salt, clathrate or solvate, with respect to the amount of PRAS40, GSK3β or phosphorylated p70S6K1 in said biological sample obtained before administration of 7- (6- (2-hydroxypropan-2-yl) pyridin-3 -i 1) -1- (trans-4-methoxycyclohexyl) -3,4-dihydropyrazine [2,3-b] pyrazin-2 (1 H) -one, or a pharmaceutically acceptable salt, clathrate or solvate thereof, indicates the inhibition of TOR kinase activity and in which the amount of PRAS40, GSK3β or phosphorylated p70S6K1 in said biological sample is measured using flow cytometry, ELISA, immunohistochemistry using specific antibodies of phosphorylation, western blotting or immunofluorescence. |
| priorityDate | 2012-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 836.