http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-266847-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_30432c021c19453629a3b69ce104640e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-22 |
| filingDate | 1961-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1961-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-266847-A1 |
| titleOfInvention | A PROCEDURE FOR THE PRODUCTION OF DERIVATIVES OF 4-HALO-SULFAMOYLBENZOIC ACID |
| abstract | The invention comprises 4-halo-3-sulphamoyl-benzoic acid derivatives of the formula <FORM:0915260/IV (b)/1> wherein Hal is bromine or chlorine, X is a lower alkoxy group or a group -N=C(R) lower alkyl, -NR1R2, or -NR1R2.HA, where in R is hydrogen or a lower alkyl group, R1 and R2 are hydrogen or lower alkyl groups or NR1R2 forms a monocyclic heterocyclic radical having fewer than 6 carbon atoms such as a morpholino, methylmorpholino, pyrrolidino, methylpyrrolidino or piperidino radical, and A represents one equivalent of a nontoxic anion, such as those derived from hydrohalic, sulphuric, phosphoric, sulphamic, p-toluenesulphonic, acetic, lactic, citric and propionic acids. The terms "lower alkyl" and "lower alkoxy" signify radicals containing not more than 5 carbon atoms. The compounds are prepared by (a) reacting a functional derivative of 4-halo-3-sulphamoylbenzoic acid, such as a cyanomethyl ester, with an alkoxyamine NH2-O- lower alkyl or a hydrazine H2N-NR1R2 (b) reacting a 4-halo-3-sulphamoylbenzoic hydrazide with an aldehyde or ketone R.CO.lower alkyl to give compounds wherein X is the group -N=C(R)lower alkyl and (c) reducing a 4-halo-3-sulphamoylbenzoyl hydrazone such as is obtainable according to (b) above, suitably by means of sodium borohydride, to give an N1-4-halo-3-sulphamoyl-benzoyl-N2-alkyl-hydrazine. Pharmaceutical preparations having diuretic activity and suitable for oral administration comprise the above compounds of the invention, in association with a solid or liquid carrier or diluent, suitably in the form of tablets, capsules, powders, suspensions or solutions. |
| priorityDate | 1960-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.