http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2667726-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fd9e6373698a4884ed7207155cb0401e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2013-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e39e123e5dcd2f73a5612c0cf3f01e5b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d27b654454a875facc23d2da53aa6737 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9a0bebb5cc5e714b88510974532ef19 |
| publicationDate | 2018-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2667726-T3 |
| titleOfInvention | Condensed pyrimidines as inhibitors of the p97 complex |
| abstract | A condensed pyrimidine compound of formula I ** Formula ** in which: A is CH2, NR1, O or S; m is an integer of 1-3; n is 0 or an integer of 1-2; the ring containing A is a ring of five or six members such that the sum of m + n is 1 or 2; Y is selected from the group consisting of hydrogen, halogen, Rc, ORc, CN, CO2H, CON (Rc) 2, C (NRc) N (Rc) 2, CH2N (Rc) 2, SO2N (Rc) 2 and SO2Rc in which each Rc is independently selected from the group consisting of hydrogen, alkyl, fluoroalkyl, aryl, aralkyl, heterocyclylalkyl, heteroaryl and any combination thereof; Z is selected from the group consisting of halogen, unsubstituted alkyl of 1 to 6 carbons, alkyl or substituted alkenyl of 1 to 4 carbons, and substituted alkoxy of 1 to 4 carbons; wherein the substituted alkyl or alkenyl group is substituted with ORa, SRa, OC (O) Ra, C (O) Ra, C (O) ORa, OC (O) N (Ra) 2, C (O) N ( Ra) 2, N (Ra) C (O) ORa, N (Ra) C (O) R8, N (Ra) C (O) N (Ra) 2, N (Ra) C (NRa) N (Ra) 2, N (Ra) S (O) tRa, S (O) tORa, S (O) tN (Ra) 2, N (Ra) 2 or PO3 (Ra) 2 in which each Ra is independently hydrogen, alkyl, fluoroalkyl, aryl, aralkyl, heterocyclylalkyl, heteroaryl or any combination thereof; and, the substituted alkoxy group is substituted with ORb, Rb, OC (O) Rb, N (Rb) 2, C (O) Rb, C (O) ORb, OC (O) N (Rb) 2, C (O ) N (Rb) 2, N (Rb) C (O) ORb, N (Rb) C (O) Rb, N (Rb) C (O) N (Rb) 2, N (Rb) C (NRb) N (Rb) 2, N (Rb) S (O) tRb, S (O) tORb, S (O) tN (Rb) 2, N (Rb) 2 or PO3 (Rb) 2 in which each Rb is independently hydrogen , alkyl, fluoroalkyl, aryl, aralkyl, heterocyclylalkyl, heteroaryl, or any combination thereof; R1 is selected from a group consisting of hydrogen, unsubstituted alkyl of 1 to 6 carbons, substituted alkyl of 1 to 4 carbons and -C (O) Rd; wherein, the substituted alkyl is substituted with ORd, SRd, OC (O) Rd, C (O) Rd, C (O) ORd, -OC (O) N (Rd) 2, C (O) N (Rd ) 2, N (Rd) C (O) ORd, N (Rd) C (O) Rd, N (Rd) C (O) N (Rd) 2, N (Rd) C (NRd) N (Rd) 2 , N (Rd) S (O) tRd, S (O) tORd, S (O) tN (Rd) 2, N (Rd) 2 or PO3 (Rd) 2; and wherein each Rd is independently selected from the group consisting of hydrogen, alkyl, fluoroalkyl, aryl, aralkyl, heterocyclylalkyl, heteroaryl, alkenyl, alkynyl or any combination thereof; each t is independently selected from an integer of 1 or 2; and, Ar is a phenyl, thiophenyl, pyridinyl, pyrrolyl, furanyl, or one of its substituted versions in which the substituent is optional, independent and optionally multiple and is an aliphatic, functional or aromatic component, in which the aliphatic component is it is selected from the group consisting of alkyl, alkenyl and alkynyl, in which the aromatic component is selected from the group consisting of aryl, aralkyl and heteroaryl, in which the functional component is selected from the group consisting of hydroxy, halogen, cyano, trifluoromethyl, trifluoromethoxy, nitro, trimethylsilanyl, ORa, SRa, OC (O) Ra, N (Ra) 2, C (O) Ra, C (O) ORa, C (O) N (Ra) 2, N (Ra) C (O) ORa, N (Ra) C (O) Ra, N (Ra) C (O) N (Ra) 2, N (Ra) C (NRa) N (Ra) 2, N (Ra) S ( O) tRa, S (O) tORa, S (O) tN (Ra) 2, Ra-N (Ra) 2 and PO3 (Ra) 2, in which t is 1 or 2, in which each Ra is independently hydrogen, alkyl, fluoroalkyl, aryl, aralkyl, heterocyclylalkyl or heteroaryl, wherein "aryl" is selected from the group consisting of phenyl, fluorenyl and naphthyl, wherein "aryl" is optionally substituted with one or more substituents selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl, hydroxy, halogen, cyano, trifluoromethyl, trifluoromethoxy, nitro, trimethylsilanyl, ORa, SRa, OC (O) Ra, N (Ra) 2, C (O) Ra, C (O) ORa, OC (O) N (Ra) 2, C (O) N ( Ra) 2, N (Ra) C (O) ORa, N (Ra) C (O) Ra, N (Ra) C (O) N (Ra) 2, N (Ra) C (NRa) N (Ra) 2, N (Ra) S (O) tRa, S (O) tORa, S (O) tN (Ra) 2, N (Ra) 2 and PO3 (Ra) 2, where t is 1 or 2, in which each Ra is independently hydrogen, alkyl, fluoroalkyl, aryl, aralkyl, heterocyclylalkyl or heteroaryl, |
| priorityDate | 2012-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 52.