| abstract |
A polypeptide comprising an amino acid sequence at least 75% identical to an amino acid sequence according to SEQ ID NO: 35, wherein (a) the polypeptide degrades a PQPQLP peptide (SEQ ID NO: 34) at pH 4 ; (b) the remainder 278 is Ser, the remainder 78 is Glu and the remainder 82 is Asp; and (c) the polypeptide comprises an amino acid change of SEQ ID NO: 67 in one or more moieties selected from the group consisting of 73, 102, 103, 104, 130, 165, 168, 169, 172 and 179, in wherein said one or more amino acid changes of SEQ ID NO: 67 include at least G130S, D169G and D179H, or said one or more amino acid changes of SEQ ID NO: 67 include at least N102D. |