| abstract |
In vitro or ex vivo procedure for increasing the immunoreactivity of cells of the immune system, comprising the transient reduction or inhibition of Cbl-b expression by using a short sequence of DNA and / or RNA complementary to a part of the target Cbl-b mRNA sequence, by contacting the cells with an antigen before or after extraction, and increasing the immunoreactivity of the cells against the antigen, and the cells comprising cells presenting antigen, PBMCs (Peripheral Blood Mononuclear Cells), T lymphocytes, B lymphocytes, monocytes, macrophages, NK cells and / or NKT cells. |