| abstract |
A compound of Formula IIIIA 2a: ** (See formula) ** in which AA3 is the side chain of a natural or unnatural amino acid; R1 and R2 can be both in the cis configuration and in the trans configuration; n is 0-3; Z is H, COR4, COR5, -CN, OR9, OCOR9, OCO2R9, NO, NO2, NR7R8, + NR7R8R9, NHSO2R9, NHCOR9, SO2R9, SOR9, SR9, halogen, NCOR9, SCOR9, an amino acid side chain, or a saturated or unsaturated heterocycle; W is H, alkyl, -OH, OR9, NH2, NHR9, NHSOR9, halogen, COR4, COR9, -CN, OCOR9, OCO2R9, NO, NO2, NR7R8, NHSO2R9, NHCOR9, SO2R9, SOR9, SR9; A is 1) H, 2) C1-C6 alkyl, 3) aryl, 4) heteroaryl, 5) heterocyclyl, 6) R3-C (O) -, 7) R3-OC (O) -, 8) R3-CH2OC (O) -, 9) R3-C (O) O-, or 10) R3-S (O) 2-; v 11) (4-amino-3-chlorobenzene) -C (O) - R1 is 1) aryl 2) heteroaryl, 3) heterocyclyl, 4) alkene C2-C6-R20, 5) SO2R5, 6) SO3R5, 7) SOR5, 8) SONHR5, 9) SO2NHR5, 10) CN, 11) CO2R5, 12) COR5, 13) PO3R5, 14) PO (OR5) 2, or 15) PO (OR5), wherein aryl, heteroaryl or heterocyclyl, are optionally substituted with one or more R30 substituents; R2 is 1) R1; or 2) H, 3) halogen, 4) haloalkyl, 5) C1-C6 alkyl, 6) C2-C6 alkene, ... |