http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2664094-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1a615b6db0acb71ee30f71f157888ba2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-48 |
| filingDate | 2013-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0e066f2accd3ce7b492101fd3dc5000 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c12c6815af885117b3514cdb7765cae2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d16ab1ef4dec38cc90397afffacc09e6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f02e6d61a214939698206afd721cdaa6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_878b99f641328e2ceca05afe34e1ef76 |
| publicationDate | 2018-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2664094-T3 |
| titleOfInvention | Preparation procedure for rilpivirine using a new intermediate |
| abstract | Method of preparing rilpivirine of formula I: ** (See formula) ** or its pharmaceutically acceptable salts, comprising: a. react the 2,4-dichloropyrimidine of formula II: ** (See formula) ** with (E) -3- (4-amino-3,5-dimethylphenyl) acrylonitrile hydrochloride of formula III: ** (See formula) ** in the presence of a tertiary amine and a suitable solvent to obtain (E) -3- (4- (2-chloropyrimidin-4-ylamino) -3,5- 40 dimethylphenyl) acrylonitrile of formula IV; and ** (See formula) ** b. Reacting (E) -3- (4- (2-Chloropyrimidin-4-ylamino) -3,5-dimethylphenyl) acrylonitrile of formula IV with 4- aminobenzonitrile of formula V in an acid and a solvent to obtain rilpivirine of formula I and optionally convert the obtained rilpivirine into a pharmaceutically acceptable acid addition salt of rilpivirine ** (See formula) ** |
| priorityDate | 2012-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 133.