http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2663469-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5a15c26ed920bde7a57742b39467c5a4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J43-003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J31-006 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J43-00 |
| filingDate | 2013-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ef400a41f75268370f8ef2f391f3881 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a9b89495fdfecd015bce6e6cda7ce7c |
| publicationDate | 2018-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2663469-T3 |
| titleOfInvention | Process for the preparation of abiraterone and abiraterone acetate |
| abstract | Process for the preparation of 3ß-hydroxyandrost-5,16-dien-17-yl-trifluoromethanesulfonate or 3ß-acetoxyandrost-5,16-dien-17-yl-trifluoromethanesulfonate (II) comprising the reaction of prasterone or prasterone acetate ( III) with a bis (trifluoromethanesulfonimide) of general formula Ar-N (Tf) 2 and a base, in which Ar is an optionally substituted aromatic radical, according to the reaction scheme: ** (See formula) ** followed of the transformation reaction of 3ß-hydroxyandrost-5,16-dien-17-yl-trifluoromethanesulfonate or 3ß-acetoxyandrost-5,16-dien-17-yl-trifluoromethanesulfonate (II), respectively, into abiraterone or abiraterone acetate ( I), by reacting the mixture resulting from said reaction with diethyl (pyridyl) borane in the presence of a palladium (II) catalyst according to the following scheme: ** (See formula) ** in which X is hydrogen or an acyl radical CH3-CO-, characterized in that said base is selected from lithium diisopropylamide, t ri-sec-lithium butyroborohydride, potassium trisec- butyroborohydride, sodium tert-butoxy and potassium tert-butoxide. |
| priorityDate | 2013-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.