http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2663399-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96ec3985e3ce9b24614fb87bf51a4f12 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J53-008 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J53-00 |
| filingDate | 2006-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cbcc3e9374de3ff177b3e177036f382c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_132e6807ee352107a70e29450eb12d9b |
| publicationDate | 2018-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2663399-T3 |
| titleOfInvention | Production process of 3-oxo-pregn-4-en-21.17-carbolactones by the free metal oxidation of 17- (3-hydroxypropyl) -3,17-dihydroxyandrostanes |
| abstract | A process for the production of 3-oxo-17α-pregn-4-en-21,17-carbolactones of formula IIIa ** (See formula) ** in which R6a is hydrogen or, together with R7a, a -CH2 group; R6b is hydrogen, or together with R7b, a -CH2 group; or a double bond; R7a is hydrogen, C1-C4 alkoxycarbonyl, C1-C4 thioacyl; R6b is hydrogen or, together with R6b, a group -CH2, R9 is hydrogen, together with R11 a double bond or together with R11 an epoxy group -O-; R10 is hydrogen or methyl; R11 is hydrogen, together with R9 a double bond or together with R9 an epoxy group -O-; R15 is hydrogen, together with R16 a -CH2 group or a double bond; R16 is hydrogen, together with R15 a -CH2 group or a double bond, which comprises the oxidation of a compound of formula Ia ** (See formula) ** in which R6a, R6b, R7a, R7b, R9, R10, R11 , R15, R16 have the same meaning as in formula IIIa, to form a compound of formula IIa; ** (See formula) ** and the subsequent elimination of water with a suitable acid to form the compound of formula IIa; characterized in that the oxidation is performed with at least 3 molar equivalents of alkaline hypochlorite, organic hypochlorite or 2-3 molar equivalents of alkaline earth hypochlorite as an oxidizing agent in the presence of catalytic amounts of a 2,2,6 N-oxide derivative , 6-tetramethylpiperidine at a pH of at least 8.0, in a biphasic solvent-water mixture, whereby the solvent is selected in such a way that both the TEMPO derivative and the compounds of formula Ia can dissolve well in the same |
| priorityDate | 2005-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 101.