http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2663009-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8d36a5393ba2d34a292205901b92681e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-351 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-344 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-346 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-331 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3231 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate | 2011-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa3884656ca0b1a8ac628b37fa47eae6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc6269c971eb941d0b67a657aac72059 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5cbb78f5df3f50ca7be801c7137dd95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_605b50d96e1b317dc0e89ff4f52e3d4e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a7a4b0ef1ca4124fef0f7ef34283c98 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23ce5a79f8b2f087a915f762a568bba4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9521f2101eed5ed8adee9944fa155e2e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a7f21af77b9e9170761e1a0e5e9222a |
| publicationDate | 2018-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2663009-T3 |
| titleOfInvention | Inhibition of RNA-mediated gene expression using short interference nucleic acids (ANic) |
| abstract | A composition comprising: I) a double-stranded short interfering nucleic acid (siNA) molecule that inhibits the expression of a target gene through RNA interference, which has a coding chain and a non-coding chain and comprises the formula ( A): Wherein, the top chain is the coding chain and the bottom chain is the non-coding chain of the double-stranded nucleic acid molecule; wherein the non-coding strand comprises a sequence having at least 15 nucleotides that are complementary to a target RNA sequence encoded by the target gene and the coding strand comprises a sequence that is complementary to the non-coding strand; each N is independently a nucleotide that is unmodified or chemically modified, or is optionally a non-nucleotide; each B is independently a terminal cap that is present or absent; (N) represents extension nucleotides, each of which is independently unmodified or chemically modified; [N] represents nucleotides at the 5 'end of the non-coding chain; X1 and X2 are independently integers from 0 to 4; X3 is an integer from 15 to 30; X4 is an integer from 12 to 27; and X5 is an integer from 1-6, provided that the sum of X4 and X5 is an integer from 15-30; and wherein (a) all of the pyrimidine nucleotides at positions NX4 are 2'-O-methyl nucleotides; (b) all purine nucleotides at positions NX4 are 2'-fluoro nucleotides; (c) all pyrimidine nucleotides at positions NX3 are 2'-O-methyl nucleotides; (d) all purine nucleotides at positions NX3 are 2'-fluoro nucleotides; (e) the nucleotide or nucleotides at position [N] are any combination of ribonucleotides, deoxyribonucleotides, 2'-O-methyl nucleotides or 2'-fluoro nucleotides; and (f) the nucleotide at position 14 from the 5 'end of the non-coding strand of said double stranded short interference nucleic acid (siNA) molecule is a 2'-deoxy-2'-fluoro nucleotide; and II) a cationic lipid comprising (13Z, 16Z) -N, N-dimethyl-3-nonyldocosa-13,16-dien-1-amine. |
| priorityDate | 2010-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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