http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2661569-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f521eb4d764415ef76757938a40d7275 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55566 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-095 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| filingDate | 2011-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de70e78d3d3432d32cc509f3e3257999 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5bc7ba1cdaa92cd77a7b88b17991e539 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d6b50a23148a53405da89f368086076 |
| publicationDate | 2018-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2661569-T3 |
| titleOfInvention | H-factor binding proteins (fHbp) with altered properties and methods of use thereof |
| abstract | An immunogenic composition comprising a non-natural factor H (fHbp) binding protein derived from fHbp ID1 (having the sequence set forth in SEQ ID NO: 1) and having a sequence identity of at least 90% with SEQ ID NO: 1, in which the unnatural fHbp has an amino acid substitution at position R41, and in which said unnatural fHbp has a lower affinity for human H factor (fH) than fHbp ID1, and generates bactericidal antibodies against N. meningitidis; wherein the amino acid substitution in R41 is R41S or R41A; or wherein the composition comprises an adjuvant selected from aluminum hydroxide, aluminum phosphate, MF59 ™, an oil-in-water emulsion, monophosphoryl lipid A or a saponin; or wherein the composition comprises vesicles of the outer membrane of Neisseria meningitidis genetically modified to express fHbp; or wherein the composition comprises genetically modified Neisseria meningitidis microvesicles to express fHbp. |
| priorityDate | 2010-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.