http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2661510-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-541 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 |
| filingDate | 2012-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e65d4f3c8ae991af7119c9217789f09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_861c455a6c736c7f1e3fb483bc8e310d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5fdebf9c3b45e79012a47e44ca9a687 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56237eb74e55c792129cc7522466d3c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b014ec97458bdc0a31f66fee613abbfd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_203ed044bd30791ac9d9abac2a3354ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba73c9bccd784adccc9791de16386b31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_891edaac8a647718ee1a6db0fcf742e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5cd22c4a109692809be3ee12c2635efa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f1f7217d5029e51f96319803dcff485 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8cdbe67a0b2dd075e4c9035808414661 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1454fc74b644247baeb1914f97a5f577 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2388dd8e081e1970c7aab9315a178b6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28fb8a9edefb8227b413e1377f9db32b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34e5b1e503fc8985c53a61437ddbecad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb722f34c319b40d1ea9462e8b526132 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5c87573386eac28cbc4c29b315e0532 |
| publicationDate | 2018-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2661510-T3 |
| titleOfInvention | Use of inhibitors of PI3K activity or function |
| abstract | A PI3K inhibitor, in which said inhibitor has an inhibitory action on the isoform of the PI3K delta, for use in the treatment of immunopathology in a subject suffering from a disease or a disorder selected from acute and cerebral malaria, by means of of functional inhibition of TLR9 of the infected subject, in which the PI3K inhibitor is selected from tetrahydro-pyrido-pyrimidine compounds of formula (I) and / or tautomers and / or N-oxides and / or pharmaceutically acceptable salts of the same, ** (See formula) ** in which: Y is selected from O or NR3; R1 is selected from phenyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, 1,2,3-triazinyl, 1,2,4-triazinyl, 1,3,5-triazinyl, or -C (O) -R4 in which R4 is selected from C1-C8 alkyl, halo-C1-C8 alkyl, hydroxy-C1-C8 alkyl, C1-C8 alkoxy-C1-C8 alkyl, C1-C8 alkyl-sulfonyl-C1-C8 alkyl, heterocyclyl , heterocyclyl-oxy, heterocyclyl-C1-C8-alkyl, cycloalkyl-C3-C12, cycloalkyl-C3-C12-alkyl-C1-C8, heteroaryl, heteroaryl-oxy, heteroaryl-C1-C8 alkyl, hydroxy, C1-alkoxy C8, amino, N-C1-C8-amino-alkyl or N, N-di-C1-C8-alkyl-amino, wherein `C1-C8-alkyl 'in N-C1-C8-amino-alkyl and N , N-di-C1-C8-alkyl-amino may be substituted or unsubstituted with halogen, hydroxy or C1-C4 alkoxy; wherein "C3-C12 cycloalkyl" in C3-C12 cycloalkyl and C3-C12-cycloalkyl-C1-C8 alkyl may be substituted or unsubstituted with 1-5 substituents independently selected from oxo, halogen, C1-alkyl C8, halo-C1-C8 alkyl, hydroxy-C1-C8 alkyl, hydroxy, C1-C8 alkoxy, C1-C8 alkoxy-C1-C8 alkyl, amino, N-C1-C8-amino-alkyl, N, N-dialkyl-C1-C8-amino, alkyl-C1-C8-carbonyl, halo-C1-C8-alkylcarbonyl, hydroxy-C1-C8-alkylcarbonyl or C1-C8-alkoxy-C1-C8-alkyl carbonyl; wherein 'heterocyclyl' is selected from oxyranyl, aziridinyl, oxetanyl, thienyl, acetylinyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, 2,3-dihydrofuranyl, 2,5-dihydrofuranyl, 2,3-dihydrothiophenyl, 1-pyrrolinyl, 2- pyrrolinyl , 3-pyrrolinyl, tetrahydropyranyl, piperidinyl, tetrahydrothiopyranyl, morpholinyl, thiomorpholinyl, piperazinyl, azepanyl, tiepanyl or oxepanyl; each of which is unsubstituted or substituted with 1-5 substituents independently selected from oxo, halogen, C1-C8 alkyl, halo-C1-C8 alkyl, hydroxy-C1-C8 alkyl, hydroxy, C1-C8 alkoxy, C1-C8-alkoxy-C1-C8-alkyl, amino, N-C1-C8-alkyl-amino, N, N-di-C1-C8-amino-alkyl, C1-C8-carbonyl, halo-alkyl- C1-C8-carbonyl, hydroxy-C1-C8-alkylcarbonyl or C1-C8-alkoxy-C1-C8-carbonyl; wherein 'heterocyclyl' can be attached to a heteroatom or a carbon atom and where the N and / or S heteroatoms can also optionally be oxidized to various oxidation states; wherein 'heteroaryl' is selected from furanyl, thiophenyl, pyrrolyl, imidazolyl, pyrazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, 1,2,5-oxadiazolyl, 1,2,4-oxadiazolyl, 1,2,3-oxadiazolyl , 1,3,4-oxadiazolyl, 1,2,5-thiadiazolyl, 1,2,4-thiadiazolyl, 1,2,3-thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,3-triazolyl, 1 , 2,4-triazolyl, 1,2,5-triazolyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, 1,2,3-triazinyl, 1,2,4-triazinyl or 1,3,5-triazinyl; each of which is unsubstituted or substituted with 1-5 substituents independently selected from halogen, C1-C8 alkyl, halo-C1-C8 alkyl, hydroxy-C1-C8 alkyl, hydroxyl, C1-C8 alkoxy, alkoxy C1-C8-C1-C8-alkyl, amino, N-C1-C8-alkyl-amino, N, N-di-C1-C8-amino, alkyl-C1-C8-carbonyl, halo-C1-alkyl C8-carbonyl, hydroxy-C1-C8-alkylcarbonyl or C1-C8-alkoxy-C1-C8-alkylcarbonyl; wherein "heteroaryl" can be attached to a heteroatom or a carbon atom and where the N and / or S heteroatoms can also optionally be oxidized to various oxidation states; R2 is selected from phenyl, naphthyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, quinolinyl or isoquinolinyl, each of which is unsubstituted or substituted with 1-5 substituents independently selected from halogen, cyano, nitrogen, C1-C8 alkyl, halo-C1-C8alkyl, hydroxy-C1-C8-alkyl, hydroxyl, C1-C8-alkoxy, C1-C8-alkoxy-C1-C8-alkyl, amino, N-C1-C8-amino-alkyl, N, N- di-C1-C8-amino-alkyl, C1-C8-carbonyl alkyl, halo-C1-C8-alkylcarbonyl, hydroxy-C1-C8-alkylcarbonyl or C1-C8-alkoxy-C1-C8- carbonyl; R3 is selected from H, C1-C4 alkyl or halo-C1-C4 alkyl; and m is selected from 0 or 1. |
| priorityDate | 2011-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 133.