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publicationDate 2018-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2661037-T3
titleOfInvention Procedures for producing a suspension of aripiprazole and a lyophilized formulation
abstract Process for producing a suspension of aripiprazole comprising the steps of: (a) combining aripiprazole in bulk and a vehicle to form a primary suspension; (b) subject the primary suspension to a first spray to form a secondary suspension; and (c) subjecting the secondary suspension to a second spray to form a final suspension, in which in the first spray of step (b), the secondary suspension is formed by spraying the primary suspension using a high shear spraying machine or a dispersion machine that applies a cutting force to a material to be processed, and in the second spray of step (c), the final suspension is formed by spraying the secondary suspension using a high pressure homogenizer.
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