abstract |
Process for preparing a glycosaminoglycan derivative that inhibits heparanase, which comprises: a) the oxidation of 10% to 100%, of residues not sulfated in 2-O- and 2N-, 3-O-, of a glycosaminoglycan, in effective conditions for converting adjacent diols and adjacent OH / NH2 into dialdehydes; b) the oxidation of the oxidized glycosaminoglycan under conditions effective to convert said dialdehydes into carboxylate groups, and wherein the glycosaminoglycan is a natural or synthetic glycosaminoglycan selected from heparin, low molecular weight heparins, heparan sulfate, optionally 2-O- and / or 2-N-desulphated. |