| abstract |
A compound that has a structure represented by the following formula (I): ** (See formula) ** in which: Y and Z are selected to form :: ** (See formula) ** in which each A1 is independently O, CR1R2, or NH, or NR1, or NR1R2 or together with another A1 forms C3-C12 cycloalkyl or C3-C12 cycloalkenyl or aryl or heteroaryl or C3-C12 heterocycloalkyl or C3-C12 heterocycloalkenyl or a 3-8 membered ring comprising C, O, S and / or N; R is selected from CF3, halogen, CN, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, NR1R2, S (O) 0-2NR1R2 or S (O) 0-2R1R2; M is substituted or unsubstituted and is selected from aryl or heteroaryl; D is selected from a bond, O, CR1R2 or NH or NR1 or NR1R2; E is selected from H, CF3, halogen, CN, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted C3-C12 cycloalkyl or substituted or unsubstituted C3-C12 cycloheteroalkyl or - ( CH2) x-C3-C12 cycloalkyl or - (CH2) x-C3-C12 cycloheteroalkyl; R1 is absent or selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and R2 is selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or COR1, or, R1 and R2 form a C3-C12 cycloalkyl or a C3-C12 cycloheteroalkyl containing O, N or S; or a pharmaceutically acceptable salt thereof. |