| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2863 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
| filingDate |
2011-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c8f48c565771dd3878e702970438b9b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa81bf759ffbd6837266a26632ac1a3f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1e5e7883207b07f19c5aa0a7bf99fed
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77acd30be3565b1681e1600b3172ac23 |
| publicationDate |
2018-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2659406-T3 |
| titleOfInvention |
Compositions and methods of use for therapeutic antibodies against protein 6 related to low density lipoproteins (LRP6) |
| abstract |
An isolated antibody or fragment thereof against a protein 6 related to low density lipoproteins (LRP6), wherein said antibody or fragment (i) binds to the propellant region 1 of LRP6, (ii) specifically inhibits signaling of propellant-dependent Wnt 1 and (iii) has a dissociation rate constant (KD) of less than 5x10-9 M determined using surface plasmon resonance, wherein said antibody or fragment comprises a heavy chain variable region CDR1 of SEQ ID NO: 1; a CDR2 heavy chain variable region of SEQ ID NO: 2; a CDR3 of the heavy chain variable region of SEQ ID NO: 3; a CDR1 of the light chain variable region of SEQ ID NO: 4; a CDR2 of the light chain variable region of SEQ ID NO: 5; and a CDR3 of the light chain variable region of SEQ ID NO: 6, wherein the antibody or fragment is monovalent or bivalent. |
| priorityDate |
2010-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |