| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71302f622b0ac050f8c54540bf33cf72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18d92c46f60af8af24e262b67381d7eb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b63e00734c7dae2e2dccd070bb2c62cb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8d329ebc42039eba20b21f1e2155e5d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_15cc4b540001c45baa07c1cfbe4567a0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7f362ad5c6099c1167f2b98b0e4cd6b8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0dca9bbeaf47ef271a0364421b75515b |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate |
2001-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f6c939d2e4b577b6f2f996c7f08f673
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfdc6151e7d3bc0b36c137f25e9c849e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56dcb82c147e0494cba5b3c7191482d8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c35e2126c96c9549f5601ee9a59b7356
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_882d42f280445e067a7bdb5b032d9d9f |
| publicationDate |
2018-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2659209-T3 |
| titleOfInvention |
Procedure to generate hypermutable organisms |
| abstract |
Method for generating a genetically stable cell in vitro comprising a mutation in a gene of interest, said method comprising the steps of: culturing a hypermutable mammalian cell comprising the gene of interest and a polynucleotide encoding an error repair hPMS2 protein of pairing the truncated peptide consisting of the 133 N-terminal amino acids of HPMS2 (hPMS2-134); test the cell to determine if the gene of interest harbors a mutation and detect the mutation; and restoring pairing error repair activity to the cell by decreasing or suppressing the expression of the polynucleotide encoding hPMS2-134, thereby generating a genetically stable cell comprising a mutation in a gene of interest. |
| priorityDate |
2000-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |