| abstract |
Isolated Pseudomonas Exotoxin A ("PE"), in which PE has a substitution of alanine, glycine, serine or glutamine instead of amino acid residue R505, in which amino acid residue R505 is defined in reference to the sequence of amino acids of the native PE according to SEQ ID NO: 1, wherein the PE optionally further comprises: (i) a substitution of alanine, valine, glycine, leucine, isoleucine or glutamine instead of the amino acid residue R490, wherein the amino acid residue R490 is defined in reference to the amino acid sequence of the native PE according to SEQ ID NO: 1; and / or (ii) a substitution of, independently, one or more of the amino acid residues E282, E285, P290, R313, N314, P319, D324, E327, E331, Q332, D403, R412, R427, E431, R432, R458, D461, R467, R513, E522, R538, E548, R551, R576, K590, and L597, as defined by SEQ ID NO: 1, by alanine, glycine, serine, or glutamine. |