http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2657451-T3
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1a0c3e4b714908382e152c4ee0b8ed0b |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4375 |
filingDate | 2014-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2018-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b5857c86831f51d218eb8385bdce90c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2c76357e6381124f851e2c4d3a5caa9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45eb05cb608d286ddca63386f987510e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca2da61504996c591f7a9a8ae3b4bdd2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f72c151103f481af75c713f62b50e1d6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2bc9f53c0881a6703ebcc902bd282e7a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94f7df3f376576328e8b6a316b5f2a48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e753b8f3b14c2735f3d0e9cea1a7d71d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5292d5077c9ccfe28343e15eda8a7528 |
publicationDate | 2018-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2657451-T3 |
titleOfInvention | Bicyclic heterocyclics as FGFR inhibitors |
abstract | A compound of formula IIIa: ** (See formula) ** or a pharmaceutically acceptable salt thereof, wherein: R2 and R5 are each independently selected from H, halo, C1-6 alkyl, C2-6 alkenyl, C2 alkynyl -6, C1-6 haloalkyl, cyclopropyl, CN, ORa, SRa, C (O) Rb, C (O) NRcRd, C (O) ORa, OC (O) Rb, OC (O) NRcRd, NRcRd, NRcC ( O) Rb, NRcC (O) ORa, NRcC (O) NRcRd, C (> = NRe) Rb, C (> = NRe) NRcRd, NRcC (> = NRe) NRcRd, NRcS (O) Rb, NRcS (O) 2Rb, NRcS (O) 2NRcRd, S (O) Rb, S (O) NRcRd, S (O) 2Rb, and S (O) 2NRcRd; R 6 is H, halo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 6-10 aryl, C 3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, CN, NO2, ORa2, SRa2, C (O) Rb2, C (O) NRc2Rd2, C (O) ORa2, OC (O) Rb2, OC (O) NRc2Rd2, NRc2Rd2, NRc2C (O) Rb2, NRc2C (O) ORa2, NRc2C (O) NRc2Rd2, C (> = NRe2) Rb2, C (> = NRe2) NRc2Rd2, NRc2C (> = NRe2) NRc2Rd2, NRc2S (O) Rb2, NRc2S (O) 2Rb2, NRc2S (O) 2NRc2 ,d, 2NRc2 S (O) Rb2, S (O) NRc2Rd2, S (O) 2Rb2, or S (O) 2NRc2Rd2; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl are each optionally substituted with 1 , 2, 3, 4, or 5 substituents independently selected from R6a; each R6a is independently selected from Cy1, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, CN, NO2, ORa2, SRa2, C (O) Rb2, C (O) NRc2Rd2, C (O) ORa2, OC (O) Rb2, OC (O) NRc2Rd2, C (> = NRe2) NRc2Rd2, NRc2C (> = NRe2) NRc2Rd2, NRc2Rd2, NRc2C (O) Rb2, NRc2C (O) ORa2, NRc2C ( O) NRc2Rd2, NRc2S (O) Rb2, NRc2S (O) 2Rb2, NRc2S (O) 2NRc2Rd2, S (O) Rb2, S (O) NRc2Rd2, S (O) 2Rb2, and S (O) 2NRc2Rd2, in which said C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from Cy1, halo, CN, NO2, Oa2, SRa2, C (O) Rb2, C (O) NRc2Rd2, C (O) ORa2, OC (O) Rb2, OC (O) NRc2Rd2, C (> = NRe2) NRc2Rd2, NRc2C (> = NRe2) NRc2Rd2, NRc2Rd2, NRc2C (O) Rb2, NRc2C (O ) ORa2, NRc2C (O) NRc2Rd2, NRc2S (O) Rb2, NRc2S (O) 2Rb2, NRc2S (O) 2NRc2Rd2, S (O) Rb2, S (O) NRc2Rd2, S (O) 2Rb2, and S (O) 2NRc2Rd2; R7 and R8 are each independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, -C (O) RA, S (O) RA, S (O) 2RA, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl, C3-10 cycloalkyl-C1-4 alkyl, (5-10 membered heteroaryl) -C1 alkyl -4, and (4-10 membered heterocycloalkyl) -C1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-heteroaryl -10 members, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl, C3-10 cycloalkyl-C1-4 alkyl, (5-10 membered heteroaryl) -C 1-4 alkyl, and (4-heterocycloalkyl -10 members) - C1-4 alkyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from R7a; each R7a is independently selected from Cy2, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, CN, NO2, ORa3, SRa3, C (O) Rb3, C (O) NRc3Rd3, C (O) ORa3, OC (O) Rb3, OC (O) NRc3Rd3, C (> = NRe3) NRc3Rd3, NRC3C (> = NRe3) NRc3Rd3, NRc3Rd3, NRc3C (O) Rb3, NRc3C (O) ORa3, NRc3C ( O) NRc3Rd3, NRc3S (O) Rb3, NRC3S (O) 2Rb3, NRc3S (O) 2NRc3Rd3, S (O) Rb3, S (O) NRc3Rd3, S (O) 2Rb3, and S (O) 2NRc3Rd3, in which said C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from Cy2, halo, CN, NO2, ORa3, SRa3, C (O) Rb3, C (O) NRc3Rd3, C (O) ORa3, OC (O) Rb3, OC (O) NRc3Rd3, C (> = NRe3) NRc3Rd3, NRC3C (> = NRe3) NRc3Rd3, NRc3Rd3, NRc3C (O) Rb3, NRc3C (O ) ORa3, NRc3C (O) NRc3Rd3, NRc3S (O) Rb3, NRc3S (O) 2Rb3, NRc3S (O) 2NRc3Rd3, S (O) Rb3, S (O) NRc3Rd3, S (O) 2Rb3, and S (O) 2NRc3Rd3; ... |
priorityDate | 2013-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 785.