http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2657240-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3b72bc0a2f48e9f1e5260dd9b0fae605 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-091 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-09 |
| filingDate | 2010-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7b7849fcf1014c4b3b046b803335f1e |
| publicationDate | 2018-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2657240-T3 |
| titleOfInvention | Synthesis procedure of beta glycerol phosphate |
| abstract | A method of preparing a compound comprising Formula (VI), the process comprising: B. contacting a compound comprising Formula (II) with a phosphorylation agent comprising Z in the presence of a proton acceptor to form a compound comprising Formula (III); C. contacting the compound comprising Formula (III) with water to form a compound comprising Formula (IV) and HZ, wherein step C further comprises (i) a first stage of division in which the addition of water leads to the formation of an organic phase and an aqueous phase; the organic phase comprising the compound comprising Formula (IV) and the aqueous phase comprising impurities such as HZ, and the aqueous layer of the mixture is removed from the mixture, removing the impurities; and (ii) a second step of dividing the reaction mixture into two immiscible organic phases by adding a non-polar hydrocarbon solvent selected from the group consisting of heptane, pentane, hexane, octane and cyclopentane, and a selected water miscible polar hydrocarbon solvent from the group consisting of methanol, ethanol and propanol, the polar hydrocarbon solvent further comprising a water concentration of 1% to 25%, which separates the reaction mixture into a phase of polar hydrocarbon solvent comprising the compound comprising the Formula ( IV) and a non-polar hydrocarbon solvent phase comprising at least one organic by-product of the reaction process; D. contacting the compound comprising Formula (IV) with a proton acceptor comprising at least one metal ion (M) to form a compound comprising Formula (V), the proton acceptor being selected from the group consisting of a metal hydroxide, a metal bicarbonate and a metal carbonate; and E. deprotecting the compound comprising Formula (V) to form the compound comprising Formula (VI) according to the following reaction scheme: ** (See scheme) ** in which: Rp is a protective group ; Z is halogen; and M is selected from the group consisting of Group IA, Group IIA, and transition metal ions. |
| priorityDate | 2009-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 162.