http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2656696-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c89ce4d9ac03f9acd8ddede1162f94d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5383 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4985 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-16 |
| filingDate | 2014-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13211c7acaadfa54e2141a9cc3c89dc7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21b7936b93f702d5fd84e43aeccd9df7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bad586c7156139dc39afa2460cf8842 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dab0466340d89593c957c5f84f0d4c72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47070f8497bfce3659ebd1960ceab9e1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a6e239837d8c1376b7e4e118208a665 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba40dd0aef8d64f11b98aee0dd88693f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23b4e0e032f8e1f0d2aa79312d2e18bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_064b090c69aae5f6958bc2b17ebf5578 |
| publicationDate | 2018-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2656696-T3 |
| titleOfInvention | Condensed tricyclic heterocyclic compounds as inhibitors of HIV integrase |
| abstract | A compound having the formula: ** Formula ** and pharmaceutically acceptable salts thereof, wherein: A is C1-C4 alkylene, C2-C4 alkenylene, arylene, C3-C7 cycloalkyl, 5- or 6-membered monocyclic heteroaryl, 4-7 membered heterocycloalkyl, -O-, -NH-C (O) -, -C (O) NH- or -C (O) -; X is O, -N (C1-C6 alkyl) - or -C (R10) (R11), such that when X> = O or -N (C1-C6 alkyl) -, then R4, R5, R6 and R7 are each different from -OR9, -N (R9) 2 or halo; each occurrence of m is independently 0 or 1; n is 0 or 1, such that when n is 0 then R4 and R5 are not present; R1 is C1-C6 alkyl, which is optionally substituted with up to 3 groups, each independently selected from C3-C7 cycloalkyl, 5- or 6-membered monocyclic heteroaryl, 4-6 membered monocyclic heterocycloalkyl, C6-C10 aryl, halo, C1-C6 haloalkyl, -OR9, -N (R9) 2, -C (O) R9, -C (O) N (R9) 2, - NHC (O) R9 and -SR9, wherein said C3-cycloalkyl group C7, said 5- or 6-membered monocyclic heteroaryl group, said 4-6 membered monocyclic heterocycloalkyl group and said C6-C10 aryl group may each be optionally and independently substituted with one or more groups, each independently selected from C1-C6-alkyl, C3-C7-cycloalkyl, 5- or 6-membered monocyclic heteroaryl, 4-6 membered monocyclic heterocycloalkyl, C6-C10 aryl, halo, C1-C6-haloalkyl, -OR9, -N (R9) 2, -C (O) R9, - C (O) N (R9) 2, -NHC (O) R9 and -SR9; R2, R5, R6, R7, R10 and R11 are each independently selected from H, -C1-C6 alkyl, C3-C7 cycloalkyl, halo, C1-C6 haloalkyl, -OR9, -N (R9) 2, -C (O) R9, -C (O) N (R9) 2 and -NHC (O) R9, wherein said C1-C6 alkyl group may optionally be substituted with one or more groups, each independently selected from halo, - OH, -O (C1-C6 alkyl), -NH2, -NH (C1-C6 alkyl), -N (C1-C6 alkyl) 2, -SH or -S (C1-C6 alkyl); R3 is H, -C1-C6 alkyl, C3-C7 cycloalkyl, C1-C6 haloalkyl, -C (O) R9, -C (O) N (R9) 2 and -NHC (O) R9, wherein said alkyl group C1-C6 can be optionally substituted with one or more groups, each independently selected from halo, -OH, -O (C1-C6 alkyl), -NH2, -NH (C1-C6 alkyl), -N (C1 alkyl -C6) 2, -SH or - S (C1-C6 alkyl); R4 is H, or R4 and R5 and the common carbon atom to which they are attached unite to form a -C (O) -endocyclic group; R8 is selected from C1-C6 alkyl, - (C1-C3 alkylene) m- (C3-C7 cycloalkyl), - (C1-C3 alkylene) m- (5- or 6-membered monocyclic heteroaryl), - (C1- alkylene C3) m- (4- to 6-membered monocyclic heterocycloalkyl) and - (C1-C3 alkylene) m- (C6-C10 aryl), wherein said C3-C7 cycloalkyl group, said 5- or 6-membered monocyclic heteroaryl group, said 4-6 membered monocyclic heterocycloalkyl group and said C6-C10 aryl group may each be optionally and independently substituted with up to 5 groups, each independently selected from C1-C6 alkyl, C3-C7 cycloalkyl, 5-monocyclic heteroaryl or 6-membered, 4- to 6-membered monocyclic heterocycloalkyl, C6-C10 aryl, halo, C1-C6 haloalkyl, -OR9, -N (R9) 2, -C (O) R9, - C (O) N (R9) 2, -NHC (O) R9 and -SR9; and each occurrence of R9 is independently selected from H, -C1-C6 alkyl, C3-C7 cycloalkyl, C6-C10 aryl, and benzyl. |
| priorityDate | 2013-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 88.